Overwhelming evidence indicates that virtually all treatment-naive tumors contain a subpopulation of cancer cells that possess some stem cell traits and properties and are operationally defined as cancer cell stem cells (CSCs).CSCs manifest inherent heterogeneity in that they may exist in an epithelial and proliferative state or a mesenchymal non-p
Background: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on data derived from adults.Trametinib is a HAIR TOUCH UP kinase inhibitor that targets MEK1/2 and has been employed in the treatment of cancers harboring mutations in the Ras pathway.Methods: We
PURPOSE: To report our experience in treating patients with failed previous open pyeloplasty by transperitoneal laparoscopic pyeloplasty.MATERIALS AND METHODS: Eleven patients with previous failed open pyeloplasty were reviewed, all of whom had undergone transperitoneallaparascopicpyeloplasty.All procedures were performed by a single team.Depending
Von Willebrand Disease (VWD) type 3 is a serious and sometimes fatal hereditary bleeding disorder.In pigs, the disease Pura Refill has been known for decades, and affected animals are used as models for the human disease.Due to the recessive mode of inheritance of VWD type 3, severe bleeding is typically seen in homozygous individuals.We sequenced
Drug rash with eosinophilia and systemic symptoms syndrome is an idiosyncratic drug nunchaku reaction characterized by fever, skin eruption, lymph node enlargement, and internal organ involvement.We report a case of a patient with pneumonia who developed clinical manifestations of fever, rash, lymphadenopathy, hypereosinophilia, and visceral involv